High-density brain imaging lab
Testing and validation of MEMS-based high-denstity neural sensors for various neurobiological applications
State-of-the-art silicon probes
closely-packed site layouts, spatial oversampling
Recent developments of devices used to measure the electrical activity of the neurons directly from the brain tissue now allow to record neuronal signals with a high spatial resolution. These so-called neural/silicon probes contain a large number of small, closely-packed sensors (electrodes) which can monitor the activity of even hundreds of neurons at the same time. However, the scientific application of these state-of-the-art devices as well as the processing and analysis of the vast amount of neural data acquired by them is still in its infancy.
One of our aims is to the comprehensively test these high-channel-count silicon probes in animal models and to develop methods to efficiently process the obtained high-resolution measurements.
Furthermore, our group intends to use these probes to examine the cellular and network mechanisms (e.g. thalamocortical rhythms) underlying various physiological (e.g. sleep, anesthesia) and pathological (e.g. epilepsy) brain states.
We are also interested in the investigation of the electrical impulses (spikes or action potentials) generated by individual neurons. The spike waveforms of neurons recorded with high spatial resolution might be exploited to help scientists to distinguish between different types of neurons in the investigated brain area.
Reference: ATLASNeuro EDC probe (http://www.atlasneuro.com/)
Please visit our Publications page for the full list.
Fiáth R, Raducanu BC, Musa S, Andrei A, Lopez CM, Welkenhuysen M, Ruther P, Aarts A, Ulbert I. Fine-scale mapping of cortical laminar activity during sleep slow oscillations using high-density linear silicon probes. (2019) JOURNAL OF NEUROSCIENCE METHODS 316: 58-70. IF: 2.668, Q2
Fiáth R, Raducanu BC, Musa S, Andrei A, Lopez CM, van Hoof C, Ruther P, Aarts A, Horváth D, Ulbert I. A silicon-based neural probe with densely-packed low-impedance titanium nitride microelectrodes for ultrahigh-resolution in vivo recordings. (2018) BIOSENSORS & BIOELECTRONICS 106: pp. 86-92. IF: 8.173, Q1/D1
George Dimitriadis, Joana P. Neto, Arno Aarts, Andrei Alexandru, Marco Ballini, Francesco Battaglia, Lorenza Calcaterra, Francois David, Richárd Fiáth, João Frazão, Jesse Geerts, Luc J. Gentet, Nick Van Helleputte, Tobias Holzhammer, Chris van Hoof, Domonkos Horváth, Gonçalo Lopes, Eric Maris, Andre Marques-Smith, Gergely Márton, Domokos Meszéna, Srinjoy Mitra, Silke Musa, Hercules Neves, Joana Nogueira, Guy A. Orban, Frederick Pothof, Jan Putzeys, Bogdan Raducanu, Patrick Ruther, Tim Schroeder, Wolf Singer, Paul Tiesinga, Istvan Ulbert, Shiwei Wang, Marleen Welkenhuysen, Adam R. Kampff. Why not record from every channel with a CMOS scanning probe? (2018) BioRxiv (Preprint)
Raducanu BC, Yazicioglu RF, Lopez CM, Ballini M, Putzeys J, Wang S, Andrei A, Rochus V, Welkenhuysen M, van Helleputte N, Musa S, Puers R, Kloosterman F, van Hoof C, Fiáth R, Ulbert I, Mitra S. Time Multiplexed Active Neural Probe with 1356 Parallel Recording Sites. (2017) SENSORS 17:(10) Paper 2388. IF: 2.677, Q2
Ayub S, Gentet LJ, Fiáth R, Schwaerzle M, Borel M, David F, Barthó P, Ulbert I, Paul O, Ruther P. Hybrid intracerebral probe with integrated bare LED chips for optogenetic studies. (2017) BIOMEDICAL MICRODEVICES 19(3):49. IF: 2.062 , Q2
Fiath R, Beregszaszi P, Horvath D, Wittner L, Aarts AA, Ruther P, Neves HP, Bokor H, Acsady L, Ulbert I. Large-scale recording of thalamocortical circuits: in vivo electrophysiology with the two-dimensional electronic depth control silicon probe. (2016) JOURNAL OF NEUROPHYSIOLOGY 116:(5) pp. 2312-2330. IF: 2.653, Q1
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